| Autor: |
Dong Rui Zhao, Yun Song Jiang, Jin Yuan Sun, He He Li, Xiao Tao Sun, Mou Ming Zhao |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Journal of Functional Foods, Vol 55, Iss , Pp 95-103 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
1756-4646 |
| DOI: |
10.1016/j.jff.2019.01.047 |
| Popis: |
Emerging data suggests that 4-methylguaiacol is not only an aroma compound but also a bioactive component of Baijiu (Chinese liquor). To verify the anti-inflammatory potential of 4-methylguaiacol, the influence of 4-methylguaiacol on the secretion of inflammatory cytokines was monitored by ELISA in LPS-induced THP-1 cell model, the regulation of 4-methylguaiacol on the NF-κB, AP-1, and Nrf2 signaling pathways was detected by real-time PCR and western blot as well. Based on the results of ELISA, 4-methylguaiacol significantly inhibited the overproduction of TNF-α, IL-1β, IL-6, IL-8, NO, and PGE2 caused by LPS. Further real-time PCR and western blot analyses revealed that 4-methylguaiacol was able to attenuate LPS-induced inflammatory response and inhibit the expression level of inflammatory cytokines and inflammasome by inducing Nrf2 signaling pathway and inactivating the NF-κB and AP-1 signaling pathways. In light of these findings, 4-methylguaiacol was an effective anti-inflammatory component natural in Baijiu. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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