Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors

Autor: Wei Xia, Jing Xie, Zhiqing Cai, Xuhua Liu, Jing Wen, Zhong-Kai Cui, Run Zhao, Xiaomei Zhou, Jiahui Chen, Xinru Mao, Zhengtao Gu, Zhimin Zou, Zhipeng Zou, Yue Zhang, Ming Zhao, Maegele Mac, Qiancheng Song, Xiaochun Bai
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-021-26302-y
Popis: Concomitant traumatic brain injury accelerates bone healing, but the mechanism is unclear. Here, the authors show that injured neurons, mainly those in the hippocampus, release osteogenic miRNA-enriched small extracellular vesicles, which targete osteoprogenitors to stimulate bone formation.
Databáze: Directory of Open Access Journals