BIOMARKERS ROLE IN THE DEVELOPMENT OF SINUS NODE DYSFUNCTION
| Autor: | L. M. Vasilets, A. V. Tuev, O. V. Khlynova, V. V. Vustina, E. A. Ratanova |
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| Jazyk: | ruština |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Российский кардиологический журнал, Vol 0, Iss 2, Pp 43-48 (2012) |
| Druh dokumentu: | article |
| ISSN: | 1560-4071 2618-7620 |
| Popis: | Aim. In patients with different types of sinus node dysfunction (SND), to study inflammation marker levels and assess their value as predictors of SND development. Material and methods. The study included 83 individuals: 63 patients with SND (the main group) and 20 controls. The main group was divided into three subgroups: Subgroup 1, with vegetative SND (VSND); Subgroup 2, with Type I and II sick sinus syndrome (SSS); and Subgroup 3, with tachy-brady syndrome, or Type III SSS. In all participants, the measurement of serum levels of inflammation markers, cardiac electrophysiological testing, and long-term electrocardiography monitoring were performed. The inflammation markers of interest included tumour necrosis factor alpha (THF-α), interleukin (IL) 6, IL-4, C-reactive protein (CRP), and fibrinogen. Results. Compared to controls, SND patients were characterised by increased levels of TNF-α and IL-6. TNF-α concentration was linked to SND type, with the highest levels observed in patients with tachy-brady syndrome. Elevated levels of inflammation markers independently predicted SND development. In particular, VSND risk was 2,5 times higher in patients with IL-6 concentration >3 pg/ml. SSS risk doubled when the levels of IL-6 increased from 2,5 pg/ml to 4 pg/ml. TNF-α levels >16 pg/ml were associated with a 1,5-fold increase in the risk of Type I-II SSS transformation into tachy-brady syndrome. Conclusion. Increased expression of inflammation cytokines in SND patients could be directly linked to pathogenetic mechanisms of this arrhythmic syndrome. |
| Databáze: | Directory of Open Access Journals |
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