Recent Update on Immunotherapy and Its Combination With Interventional Therapies for Hepatocellular Carcinoma

Autor: Jin-Tao Huang, Shuai Zhang, Yi-Han Yang, Zi-Chen Zhang, Nan Jiang, Wan-Ci Li, Jian Shen, Bin-Yan Zhong, Xiao-Li Zhu
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Clinical Medicine Insights: Oncology, Vol 16 (2022)
Druh dokumentu: article
ISSN: 1179-5549
11795549
DOI: 10.1177/11795549221134832
Popis: Hepatocellular carcinoma (HCC) is one of the most common and deadly malignancies worldwide. Approximately, 80% of patients are initially diagnosed at intermediate or advanced stages, which means that curative therapies are unable to be performed. In most cases, systemic treatment is ineffective, especially when conventional cytotoxic agents are used. Sorafenib has been the only systemic agent proven to be effective in treating advanced HCC for over a decade. The rapid development of immunotherapy has remarkably revolutionized the management of advanced HCC. Besides, the combination of immunotherapy with molecular targeted agents or locoregional treatments is emerging as an effective tool for enhancing immunity. In the review, an overview of immunotherapy and its combination therapies for HCC is presented.
Databáze: Directory of Open Access Journals
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