Long‐term maternal cardiometabolic outcomes 22 years after gestational diabetes mellitus

Autor: Greg E Tutino, Claudia HT Tam, Riza Ozaki, Lai Yuk Yuen, Wing Yee So, Michael HM Chan, Gary TC Ko, Xilin Yang, Juliana CN Chan, Wing Hung Tam, Ronald CW Ma
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Journal of Diabetes Investigation, Vol 11, Iss 4, Pp 985-993 (2020)
Druh dokumentu: article
ISSN: 2040-1124
2040-1116
DOI: 10.1111/jdi.13209
Popis: Abstract Aims/Introduction Women with gestational diabetes mellitus are at increased risk for type 2 diabetes. We characterized the association between maternal glycemia during pregnancy with long‐term outcomes. Methods and Methods In this prospective nested case–cohort study, participants were recalled for follow up with detailed evaluation including oral glucose tolerance test at 8, 15 and 22 years. Logistic regression was used to estimate the risk of developing impaired glucose tolerance/type 2 diabetes and metabolic syndrome at follow up. The association between maternal glycemia at pregnancy and follow up was evaluated by linear regression. We also charted trajectory of β‐cell function during follow up. Results The analysis included 121 women with a mean follow‐up period of 22.5 years, and a mean age of 50.3 years. Gestational diabetes was associated with an adjusted odds ratio of 2.48 (95% confidence interval 1.03–5.99) for combined diabetes/impaired glucose tolerance at follow up (P = 0.04). Women with a pre‐pregnancy body mass index ≥23 had an odds ratio of 5.43 (95% confidence interval 1.87–15.72) for metabolic syndrome at follow up, compared with those with body mass index
Databáze: Directory of Open Access Journals
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje