Deep Brain Stimulation in Multiple System Atrophy Mimicking Idiopathic Parkinson's Disease

Autor: Navamayooran Thavanesan, Martin Gillies, Michael Farrell, Alex L. Green, Tipu Aziz
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Zdroj: Case Reports in Neurology, Vol 6, Iss 3, Pp 232-237 (2014)
Druh dokumentu: article
ISSN: 1662-680X
DOI: 10.1159/000368571
Popis: Deep brain stimulation (DBS) is approved for idiopathic Parkinson's disease (IPD) but has a poor evidence base in Parkinson-plus syndromes such as multiple system atrophy (MSA). We describe the clinical and neuropathological findings in a man who was initially diagnosed with IPD, in whom DBS was unsuccessful, and in whom MSA was unexpectedly diagnosed at a subsequent autopsy. This case report highlights that DBS is often unsuccessful in MSA and also demonstrates that MSA can masquerade as IPD, which may explain treatment failure in a small group of patients apparently suffering from Parkinson's disease. Additionally, it also presents a case with an unusually long duration of disease prior to death, comparable only to a handful of other cases in the literature.
Databáze: Directory of Open Access Journals