Long-term methylphenidate use for children and adolescents with attention deficit hyperactivity disorder and risk for depression, conduct disorder, and psychotic disorder: a nationwide longitudinal cohort study in South Korea

Autor: Jimyung Park, Dong Yun Lee, Chungsoo Kim, Yo Han Lee, Su-Jin Yang, Sangha Lee, Seong-Ju Kim, Jeewon Lee, Rae Woong Park, Yunmi Shin
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Child and Adolescent Psychiatry and Mental Health, Vol 16, Iss 1, Pp 1-9 (2022)
Druh dokumentu: article
ISSN: 1753-2000
DOI: 10.1186/s13034-022-00515-5
Popis: Abstract Background Methylphenidate (MPH) is the most frequently prescribed medication for the treatment of attention deficit hyperactivity disorder (ADHD). However, the safety of its long-term use remain unclear. In particular, real-world evidence of long-term MPH treatment regarding the risk of depression, conduct disorders, and psychotic disorders in children and adolescents is needed. This study aimed to compare the risks of depression, conduct disorder, and psychotic disorder between long- and short-term MPH treatments in children and adolescents. Methods This population-based cohort study used a nationwide claims database of all patients with ADHD in South Korea. Patients aged less than 18 years who were prescribed MPH were included in the study. Long- and short-term MPH were defined as > 1 year, and
Databáze: Directory of Open Access Journals
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