Cognition and the Default Mode Network in Children with Sickle Cell Disease: A Resting State Functional MRI Study.
| Autor: | Raffaella Colombatti, Marta Lucchetta, Maria Montanaro, Patrizia Rampazzo, Mario Ermani, Giacomo Talenti, Claudio Baracchini, Angela Favero, Giuseppe Basso, Renzo Manara, Laura Sainati |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | PLoS ONE, Vol 11, Iss 6, p e0157090 (2016) |
| Druh dokumentu: | article |
| ISSN: | 1932-6203 80952658 |
| DOI: | 10.1371/journal.pone.0157090 |
| Popis: | Cerebrovascular complications are frequent events in children with sickle cell disease, yet routinely used techniques such as Transcranial Doppler (TCD), Magnetic Resonance (MRI) and Angiography (MRA), insufficiently explain the cause of poor cognitive performances. Forty children with SS-Sβ° (mean age 8 years) underwent neurocognitive evaluation and comprehensive brain imaging assessment with TCD, MRI, MRA, Resting State (RS) Functional MRI with evaluation of the Default Mode Network (DMN). Sixteen healthy age-matched controls underwent MRI, MRA and RS functional MRI.Children with SCD display increased brain connectivity in the DMN even in the absence of alterations in standard imaging techniques. Patients with low neurocognitive scores presented higher brain connectivity compared to children without cognitive impairment or controls, suggesting an initial compensatory mechanism to maintain performances. In our cohort steady state haemoglobin level was not related to increased brain connectivity, but SatO2 |
| Databáze: | Directory of Open Access Journals |
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