Autor: |
Muhammad Aslam, Itrat Anis, Nighat Afza, Lubna Iqbal, Samina Iqbal, Ajaz Hussain, Rashad Mehmood, Muhammad Tahir Hussain, Muhammad Khalid, Haq Nawaz |
Jazyk: |
angličtina |
Rok vydání: |
2016 |
Předmět: |
|
Zdroj: |
Journal of Saudi Chemical Society, Vol 20, Iss 1, Pp 45-48 (2016) |
Druh dokumentu: |
article |
ISSN: |
1319-6103 |
DOI: |
10.1016/j.jscs.2012.09.009 |
Popis: |
Three biologically active new Schiff bases, 2-[(3-hydroxybenzylidene)amino]phenol 5, 2-[(4-hydroxybenzylidene)amino]phenol 6 and 4-[(2-hydroxyphenylimino)methyl]benzene-1,3-diol 7, were synthesized by the reaction of 2-aminophenol 1 with three different hydroxyl-benzaldehydes 2–4. They were characterized by spectroscopic analysis (IR, 1H NMR, EI-MS) along with elemental analyses. The products were biological screened out for antioxidant, lipoxygenase inhibition, antibacterial and urease inhibition activities. The compounds 5 and 6 showed potent while 7 showed moderate antioxidant activity. Compound 6 showed potent whereas 5 and 7 showed significant lipoxygenase inhibition activity. All the target compounds showed excellent activities against Staphylococcus intermedius, Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Salmonella typhi bacteria. All the compounds showed non-significant activity against urease enzyme. |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
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