| Autor: |
Amel Bouaziz, Seddik Khennouf, Musa Abu Zarga, Shtaywy Abdalla |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Bangladesh Journal of Pharmacology, Vol 14, Iss 1 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
1991-0088 |
| Popis: |
The objective of this study was to evaluate the in vitro anti-oxidant, hypo-tensive and the diuretic activities of Origanum glandulosum leaves in rat. Chemical analysis revealed the isolation of katuranin and 5-isopropyl-3-methylphenol. Ethyl acetate extract possessed highest scavenging activity against DPPH and hydroxyl radicals. Intravenous administration of extracts (0.04 to 12 mg/kg body weight) dose-dependently decreased the blood pressure (systolic, diastolic and mean) of the anesthetized rat. Methanol extract showed dose-dependent diuretic activity by increasing the urine output (77%) and the urinary excretion of sodium and potassium. In conclusion, this study supports the use of O. glansulosum in traditional medicine as hypotensive and diuretic agents. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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