| Autor: |
Roberto M. Saraiva, Mauro Felippe F. Mediano, Marcel S.B. Quintana, Gilberto Marcelo Sperandio da Silva, Andréa R. Costa, Andréa S. Sousa, Luiz Henrique C. Sangenis, Fernanda S.N.S. Mendes, Henrique H. Veloso, Sergio S. Xavier, Marcelo T. Holanda, Alejandro Marcel Hasslocher-Moreno |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
International Journal of Cardiology: Heart & Vasculature, Vol 38, Iss , Pp 100955- (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2352-9067 |
| DOI: |
10.1016/j.ijcha.2022.100955 |
| Popis: |
Background: Patients with chronic Chagas disease (CD) cardiomyopathy have a high mortality. We evaluated if two-dimensional (2D) strain (ε) parameters provide independent predictors of progression to CD cardiomyopathy and all-cause mortality. Methods: A total of 408 patients with chronic CD (58.6% women; 53 ± 11 years; clinical forms: indeterminate 34.1%, cardiac 57.6%, digestive 1.2%, cardiodigestive 7.1%) were consecutively included in this single-center prospective longitudinal study. Echocardiographic evaluation included left atrial and left ventricular (LV) function on ε analyses. Primary end-point was a composite of all-cause mortality or heart transplant. Secondary end-point was CD progression defined as the occurrence of changes typical of CD in electrocardiogram, sustained ventricular tachycardia, wall motion abnormalities, or heart failure among patients with the indeterminate form at baseline. Multivariable Cox-proportional-hazards regression analyses were performed to test if 2D ε parameters were associated with the studied end-points. P values |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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