Maximum morning home systolic blood pressure is an indicator of the development of diabetic nephropathy: The KAMOGAWA‐HBP study

Autor: Takuro Okamura, Emi Ushigome, Nobuko Kitagawa, Chikako Oyabu, Toru Tanaka, Goji Hasegawa, Naoto Nakamura, Masayoshi Ohnishi, Sei Tsunoda, Hidetaka Ushigome, Isao Yokota, Masahide Hamaguchi, Mai Asano, Masahiro Yamazaki, Michiaki Fukui
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Journal of Diabetes Investigation, Vol 10, Iss 6, Pp 1543-1549 (2019)
Druh dokumentu: article
ISSN: 2040-1124
2040-1116
DOI: 10.1111/jdi.13040
Popis: Abstract Aims/Introduction The maximum value of home systolic blood pressure is correlated with damage to target organs, including diabetic nephropathy. However, the precise relationship between the development of diabetic nephropathy and maximum home systolic blood pressure has not been elucidated. Materials and Methods In this prospective 2‐year cohort subanalysis of the KAMOGAWA‐HBP study, the patient population was 477 Japanese patients with normoalbuminuria. We investigated the effects of mean and maximum home blood pressure on the development of diabetic nephropathy, which we defined as a urinary albumin excretion value ≥30 mg/g creatinine. Among the 477 patients, 67 developed diabetic nephropathy. Results In our multivariate logistic regression analyses, the maximum morning home systolic blood pressure was significantly positively associated with the development of diabetic nephropathy after adjusting for patient sex and age, smoking status, the diabetes mellitus duration, body mass index, creatinine, total cholesterol, hemoglobin A1c, and antihypertensive medication use (odds ratio 1.21, 95% confidence interval 1.03–1.42, P = 0.021). Conclusions Maximum home blood pressure can be identified at a glance, and its measurement would thus be helpful to healthcare providers who treat patients with diabetes and normoalbuminuria.
Databáze: Directory of Open Access Journals
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