Neuroanatomy of melanocortin-4 receptor pathway in the mouse brain

Autor: Wang Kun, Mao Wei, Zhang Xiaoyu, Zhao Yufei, Fan Kuikui, Pan Deng, Liu Haodong, Li Penghui, Hai Rihan, Du Chenguang
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Open Life Sciences, Vol 15, Iss 1, Pp 580-587 (2020)
Druh dokumentu: article
ISSN: 2391-5412
DOI: 10.1515/biol-2020-0063
Popis: Melanocortin-4 receptors (MC4Rs) are key regulators of energy homeostasis and adipose deposition in the central nervous system. Considering that MC4R expression regions and function-related research mainly focus on the paraventricular nucleus (PVN), little is known about their distribution throughout the mouse brain, although its messenger RNA distribution has been analyzed in the rat. Therefore, MC4R protein localization in mouse neurons was the focus of this study.
Databáze: Directory of Open Access Journals