Simultaneous copy number losses within multiple subtelomeric regions in early-onset type 2 diabetes mellitus.

Autor: Shinjiro Kodama, Tetsuya Yamada, Junta Imai, Shojiro Sawada, Kei Takahashi, Sohei Tsukita, Keizo Kaneko, Kenji Uno, Yasushi Ishigaki, Yoshitomo Oka, Hideki Katagiri
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Zdroj: PLoS ONE, Vol 9, Iss 4, p e88602 (2014)
Druh dokumentu: article
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0088602
Popis: Genetic factors play very important roles in the onset and progression of type 2 diabetes mellitus (T2DM). However, the genetic factors correlating with T2DM onset have not as yet been fully clarified. We previously found that copy number losses in the subtelomeric region on chromosome 4p16.3 were detected in early-onset Japanese T2DM patients (onset age
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