| Autor: |
Yuki Takeuchi, Hiroki Mizukami, Kazuhiro Kudoh, Sho Osonoi, Takanori Sasaki, Hanae Kushibiki, Saori Ogasawara, Yutaro Hara, Akiko Igawa, Xuekai Pan, Takahiro Yamada, Keisuke Yamazaki, Tatsuya Mikami, Makoto Daimon, Soroku Yagihashi, Kenichi Hakamada, Shigeyuki Nakaji |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Neurobiology of Disease, Vol 173, Iss , Pp 105839- (2022) |
| Druh dokumentu: |
article |
| ISSN: |
1095-953X |
| DOI: |
10.1016/j.nbd.2022.105839 |
| Popis: |
Small fibre neuropathy (SFN) is an initial pathology of diabetic polyneuropathy (DPN). Serum lipopolysaccharide binding protein levels are positively correlated with the pain threshold in the foot, suggesting that the abundance of gut Gram-negative bacilli, which are a source of lipopolysaccharides, may be involved in the development of DPN. Furthermore, the abundance of the gut and oral microbiota is assumed to be involved in the pathogenesis of diabetes. Nevertheless, the association between SFN and the microbiota has not been clarified. A total of 1056 individuals were recruited in the 2018 Iwaki Health Promotion Project. Pain sensation was evaluated based on the pain threshold from intraepidermal electrical stimulation (PINT). Patients with PINT scores |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full Text from ScienceDirect