| Autor: |
Laura Parada-Niño, Luisa Fernanda Castillo-León, Adrien Morel |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Journal of Pregnancy, Vol 2022 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2090-2735 |
| DOI: |
10.1155/2022/3851225 |
| Popis: |
Preeclampsia (PE) is a hypertensive disease that affects pregnant women after 20 weeks of gestation. This disease is associated with an important risk of maternal and fetal mortality. PE is described as a placental pathology because, after delivery, most women recover normal arterial pressure. Poor invasion of the spiral arteries is a phenomenon well described in PE; this leads to a hypoxic uterine bed and imbalance of antiangiogenic and proangiogenic factors in the uteroplacental region, which in turn triggers the disease phenotype. The causes of the pathology are unclear; nevertheless, numerous approaches, including next-generation sequencing, association, and case control and miRNA studies, have shed light on the genetic/molecular basis of PE. These studies help us better understand the disease to advance new treatment strategies. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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