Elusive treatment for human rhinosporidiosis
| Autor: | Jeshina Janardhanan, Shalom Patole, Lalee Varghese, V. Rupa, Amit Jiwan Tirkey, George M. Varghese |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | International Journal of Infectious Diseases, Vol 48, Iss C, Pp 3-4 (2016) |
| Druh dokumentu: | article |
| ISSN: | 1201-9712 1878-3511 |
| DOI: | 10.1016/j.ijid.2016.04.013 |
| Popis: | Objectives: The aim of this study was to clarify the contentious taxonomic classification of Rhinosporidium seeberi, the cause of human rhinosporidiosis, which may have treatment implications. Methods: PCR was used to amplify the internal transcribed spacer (ITS)-2 region from the genomic DNA of the aetiological agent obtained from a sample of human rhinosporidiosis lesions. The amplicon was sequenced and the organism identified using the Basic Local Alignment Search Tools (BLAST). Results: Phylogenetic analysis revealed that the aetiological agent clustered along with the R. seeberi isolated from humans and also with Amphibiocystidium ranae from frogs. This organism is a member of the order Dermocystida in the class Mesomycetozoea. A patient with disseminated rhinosporidiosis did not respond to conventional therapy with dapsone and surgical excision, and treatment with amphotericin B also proved futile. Conclusion: An effective treatment for R. seeberi—a eukaryote belonging to the class Mesomycetozoea—is still elusive. |
| Databáze: | Directory of Open Access Journals |
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