Pituitary adenoma consistency affects postoperative hormone function: a retrospective study

Autor: Dario De Alcubierre, Giulia Puliani, Alessia Cozzolino, Valeria Hasenmajer, Marianna Minnetti, Valentina Sada, Valentina Martines, Antonella Zaccagnino, Andrea Gennaro Ruggeri, Riccardo Pofi, Emilia Sbardella, Mary Anna Venneri
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: BMC Endocrine Disorders, Vol 23, Iss 1, Pp 1-12 (2023)
Druh dokumentu: article
ISSN: 1472-6823
DOI: 10.1186/s12902-023-01334-1
Popis: Abstract Background Tumor consistency recently emerged as a key factor in surgical planning for pituitary adenomas, but its impact on postoperative endocrine function is still unclear. Our study aimed to evaluate the impact of tumor consistency on the development of postoperative pituitary deficiencies. Methods Single-center, retrospective analysis of consecutive pituitary surgeries performed between January 2017 and January 2021 at Policlinico Umberto I in Rome. All patients underwent radiological and biochemical evaluations at baseline, and hormone assessments 3 and 6 months after pituitary surgery. Postoperative MRI studies were used to determine resection rates following surgery. Data on tumor consistency, macroscopic appearance, neurosurgical approach, and intraoperative complications were collected. Results Fifty patients [24 women, mean age 57 ± 13 years, median tumor volume 4800 mm3 [95% CI 620–8828], were included. Greater tumor volume (χ2 = 14.621, p = 0.006) and male sex (χ2 = 12.178, p
Databáze: Directory of Open Access Journals
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