Construction and evaluation of a risk model for adverse outcomes of necrotizing enterocolitis based on LASSO-Cox regression

Autor: HaiJin Zhang, RongWei Yang, Yuan Yao
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Frontiers in Pediatrics, Vol 12 (2024)
Druh dokumentu: article
ISSN: 2296-2360
DOI: 10.3389/fped.2024.1366913
Popis: ObjectiveThis study aimed to develop a nomogram to predict adverse outcomes in neonates with necrotizing enterocolitis (NEC).MethodsIn this retrospective study on neonates with NEC, data on perinatal characteristics, clinical features, laboratory findings, and x-ray examinations were collected for the included patients. A risk model and its nomogram were developed using the least absolute shrinkage and selection operator (LASSO) Cox regression analyses.ResultsA total of 182 cases of NEC were included and divided into a training set (148 cases) and a temporal validation set (34 cases). Eight features, including weight [p = 0.471, HR = 0.99 (95% CI: 0.98–1.00)], history of congenital heart disease [p
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