Septic arthritis: immunopathogenesis, experimental models and therapy

Autor: Priscila Maria Colavite, Alexandrina Sartori
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Zdroj: Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 20, Iss 0 (2014)
Druh dokumentu: article
ISSN: 1678-9199
DOI: 10.1186/1678-9199-20-19
Popis: Septic arthritis is an inflammatory disease of the joints that is started by an infection whose most common agent is Staphylococcus aureus. In this review we discuss some of the most arthritogenic bacterial factors and the contribution of innate and specific immune mechanisms to joint destruction. Special emphasis is given to the induction of experimental arthritis by S. aureus in mice. The improvement of therapy by association of antibiotics with down-modulation of immunity is also included.
Databáze: Directory of Open Access Journals