Overexpression of miR-10b in colorectal cancer patients: Correlation with and E-cadherin expression
| Autor: | Rania Abdelmaksoud-Dammak, Nour Chamtouri, Mouna Triki, Amena Saadallah-Kallel, Wajdi Ayadi, Slim Charfi, Abdelmajid Khabir, Lobna Ayadi, Tahia Sallemi-Boudawara, Raja Mokdad-Gargouri |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Tumor Biology, Vol 39 (2017) |
| Druh dokumentu: | article |
| ISSN: | 1423-0380 10104283 |
| DOI: | 10.1177/1010428317695916 |
| Popis: | MicroRNAs are emergent players of epigenetics that function as oncogenes or tumor suppressors and that have been implicated in regulating diverse cellular pathways. MiR-10b is an oncogenic microRNA involved in tumor invasion and metastasis in various cancers. Our data have shown that miR-10b is overexpressed in colorectal cancer samples in comparison with non-tumorous adjacent mucosa (p = 0.0025) and that it is associated with severe features such as tumor size >5 cm (p = 0.023), distant metastasis (p = 0.0022), non-differentiated tumors (p = 0.016), and vascular invasion (p = 0.01). Regarding the regulation of its expression, positive correlation between the loss of miR-10b and aberrant DNA methylation (p = 0.02) as well as a loss of TWIST-1 messenger RNA (p = 0.018) have been observed. Furthermore, expression analysis of the downstream miR-10b targets has shown that there are associations between low HOXD10 messenger RNA and E-cadherin protein levels (p |
| Databáze: | Directory of Open Access Journals |
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