Effects of Yarrow (Achillea millefolium) Extract on Acute Lung Injury: An Experimental Study
| Autor: | Burak Yaşar, Mervan Bekdaş, Selma Erdoğan Düzcü, Ayhan Çetinkaya, Murat Alışık, Arzu Binici Yıldırım, Muhammed Furkan Bekdaş |
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| Jazyk: | English<br />Turkish |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Journal of Pediatric Emergency and Intensive Care Medicine, Vol 11, Iss 3, Pp 151-157 (2024) |
| Druh dokumentu: | article |
| ISSN: | 2146-2399 2148-7332 |
| DOI: | 10.4274/cayd.galenos.2024.13284 |
| Popis: | Introduction: Pro-inflammatory/anti-inflammatory cytokine and oxidant/antioxidant imbalances develop in acute respiratory distress syndrome cases, a significant cause of morbidity and mortality in childhood. This study aims to investigate whether Achillea millefolium, with its antioxidant and anti-inflammatory effects, can be used in the treatment of acute lung injury. Methods: A total of 36 male Wistar rats were divided into four groups. Acute lung injury was induced by cecal ligation and puncture (CLP). Serum samples were analyzed for TNF-α, IL-10, native thiol, total thiol, and disulfide levels. Lung samples were examined using hematoxylin-eosin staining. Results: A significant difference was observed in TNF-α values among groups (p=0.003). CLP group showed higher TNF-α values compared to the control group (50.88±5.21 vs. 34.13±9.89 pg/mL, p=0.002), and histologically demonstrated increased scores of lymphocytes, fibroblasts, histiocytes, neutrophils, hemorrhage, and congestion (p=0.006, p0.05). Conclusion: This study suggests that Achillea millefolium, with its anti-inflammatory effect, may be used in the treatment of acute lung injury. However, clinical studies are needed to support these findings. |
| Databáze: | Directory of Open Access Journals |
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