Sequential thrombosis and bleeding in a woman with a prolonged activated partial thromboplastin time

Autor: Pearce Michael I, Spencer Akpan, Ames Paul RJ
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Zdroj: Thrombosis Journal, Vol 9, Iss 1, p 16 (2011)
Druh dokumentu: article
ISSN: 1477-9560
DOI: 10.1186/1477-9560-9-16
Popis: Abstract Simultaneous or sequential haemorrhage and thrombosis in the presence of a prolonged activated partial thromboplastin time (aPTT) is a rare occurrence: we describe the case a 37 year old lady who developed post-delivery deep vein thrombosis treated with low molecular heparin and warfarin followed a week later by extensive bruising over legs and forearms, a significant drop in haemoglobin and a very prolonged aPTT. Further tests revealed an acquired factor VIII inhibitor at 35 Bethesda Units. We discuss the clinical and laboratory implications and provide a literature review of simultaneous thrombophilia and haemophilia in the presence of a prolonged aPTT.
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