Reversible glycosidic switch for secure delivery of molecular nanocargos

Autor: Pierre-Alain Burnouf, Yu-Lin Leu, Yu-Cheng Su, Kenneth Wu, Wei-Chi Lin, Steve R. Roffler
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-018-04225-5
Popis: Retention of drugs loaded into liposomes is a major challenge to effective targeted drug delivery. Here, the authors report on the modification of drugs with a glycosidic pH sensitive switch to improve encapsulation and retention of drugs and demonstrate application in an in vivo cancer model.
Databáze: Directory of Open Access Journals