The Chemical Scaffold of Theranostic Radiopharmaceuticals: Radionuclide, Bifunctional Chelator, and Pharmacokinetics Modifying Linker

Autor: Holis Abdul Holik, Faisal Maulana Ibrahim, Angela Alysia Elaine, Bernap Dwi Putra, Arifudin Achmad, Achmad Hussein Sundawa Kartamihardja
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Molecules, Vol 27, Iss 10, p 3062 (2022)
Druh dokumentu: article
ISSN: 1420-3049
DOI: 10.3390/molecules27103062
Popis: Therapeutic radiopharmaceuticals have been researched extensively in the last decade as a result of the growing research interest in personalized medicine to improve diagnostic accuracy and intensify intensive therapy while limiting side effects. Radiometal-based drugs are of substantial interest because of their greater versatility for clinical translation compared to non-metal radionuclides. This paper comprehensively discusses various components commonly used as chemical scaffolds to build radiopharmaceutical agents, i.e., radionuclides, pharmacokinetic-modifying linkers, and chelators, whose characteristics are explained and can be used as a guide for the researcher.
Databáze: Directory of Open Access Journals