Ent-kaurane diterpenoids and other constituents from the stem of Xylopia laevigata (Annonaceae)
| Autor: | Dayanne Meneses Silva, Emmanoel Vilaça Costa, Paulo Cesar de Lima Nogueira, Valéria Regina de Souza Moraes, Sócrates Cabral de Holanda Cavalcanti, Marcos José Salvador, Luis Henrique Gonzaga Ribeiro, Fernanda Ramos Gadelha, Andersson Barison, Antonio Gilberto Ferreira |
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| Jazyk: | English<br />Spanish; Castilian<br />Portuguese |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Química Nova, Vol 35, Iss 8, Pp 1570-1576 (2012) |
| Druh dokumentu: | article |
| ISSN: | 1678-7064 0100-4042 |
| DOI: | 10.1590/S0100-40422012000800015 |
| Popis: | Phytochemical investigation of the hexane extract from the stem of Xylopia laevigata led to the isolation of the ent-kaurane diterpenoids, ent-kaur-16-en-19-oic acid, 4-epi-kaurenic acid, ent-16β-hydroxy-17-acetoxy-kauran-19-al, ent-3β-hydroxy-kaur-16-en-19-oic acid, and ent-16β,17-dihydroxy-kauran-19-oic acid, as well as spathulenol and a mixture of β-sitosterol, stigmasterol and campesterol. The identification of the compounds was performed on the basis of spectrometric methods including GC-MS, IR, and 1D and 2D NMR. Potent larvicidal activity against Aedes aegypti larvae with LC50 of 62.7 µg mL-1 was found for ent-3β-hydroxy-kaur-16-en-19-oic acid. This compound also showed significant antifungal activity against Candida glabrata and Candida dubliniensis with MIC values of 62.5 µg mL-1. |
| Databáze: | Directory of Open Access Journals |
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