Ocular Findings of Pediatric Dry Eye Related to Graft-Versus-Host Disease

Autor: Pınar Bingöl Kızıltunç, Tuna Çelik Büyüktepe, Fatime Nilüfer Yalçındağ, Mehmet Ertem, Elif İnce, Talia İleri, Huban Atilla
Jazyk: English<br />Turkish
Rok vydání: 2021
Předmět:
Zdroj: Türk Oftalmoloji Dergisi, Vol 51, Iss 3, Pp 134-138 (2021)
Druh dokumentu: article
ISSN: 1300-0659
2147-2661
DOI: 10.4274/tjo.galenos.2020.88137
Popis: Objectives:To evaluate the frequency and findings of dry eye associated with ocular graft-versus-host disease (GVHD) in pediatric hematopoietic stem cell transplantation (HSCT) patients.Materials and Methods:Retrospectively the records of pediatric patients with ocular GVHD were evaluated and ophthalmologic examination findings as well as Schirmer test results, tear film break-up time, and corneal staining grades were recorded. In severe dry eye patients topical cyclosporine-A was prescribed and the results were evaluated.Results:GVHD was detected in 51 (23.4%) of 218 HSCT patients, 4 of whom died during follow-up. Thirty (63.8%) of the remaining 47 patients had chronic ocular GVHD and 4 patients with severe dry eye were treated with topical cyclosporine-A with a median follow-up of 12.1 months. Severe dry eye symptoms and findings significantly improved in 2 patients. However, 1 patient had to stop treatment due to side effects.Conclusion:In children, chronic ocular GVHD is a common finding of GVHD after HSCT. Therefore, these patients should be examined periodically for dry eye.
Databáze: Directory of Open Access Journals