Quercetin reduce cardiomyocytes damage in type 2 diabetic rats
| Autor: | Asri Hendrawati, Nadhir Nadhir |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | Universa Medicina, Vol 33, Iss 3, Pp 185-191 (2014) |
| Druh dokumentu: | article |
| ISSN: | 1907-3062 2407-2230 |
| DOI: | 10.18051/UnivMed.2014.v33.185-191 |
| Popis: | BACKGROUND Diabetes mellitus (DM) is a group of metabolic diseases which are characterized by hyperglycemia, resulting in various complications. A major macrovascular complication of DM is cardiac failure due to cardiomyopathy. Hyperglycemia increases oxidative stress, so an oxidative-stress reducing therapeutic agent is required, e.g. the antioxidant quercetin. The aim of this study was to assess the effects of quercetin in reducing damage to cardiomyocytes of type 2 diabetic rats. METHODS This research is an experimental study using 40 rats. With simple random allocation, rats were divided into eight groups, then type 2 diabetes mellitus was induced using streptozotocin (5 rats per group). The test material was quercetin given at doses of 5, 20 and 80 mg/kgBW/day orally for 4 weeks. Each single dose of quercetin was given in combination with glibenclamide 5 mg/ kgBW/day. After 4 weeks the rats were decapitated and the cardiac tissues taken to quantify the percentage of cell damage after hematoxylin-eosin staining (HE). RESULTS Quercetin at a dose of 80 mg/kgBW/day can lower cardiomyocyte damage better than quercetin at doses of 5 or 20 mg/kgBW/day. A combination of quercetin and glibenclamide can significantly lower levels of cardiomyocyte damage better than quercetin without glibenclamide (p |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|