Clinical Diagnosis and Treatment Recommendations for Immune Checkpoint Inhibitor-related Hematological Adverse Events

Autor:	Junling ZHUANG, Jingting ZHAO, Xiaoxiao GUO, Jiaxin ZHOU, Lian DUAN, Wei QIU, Xiaoyan SI, Li ZHANG, Yue LI, Xiaowei LIU, Hanping WANG, Daobin ZHOU
Jazyk:	čínština
Rok vydání:	2019
Předmět:	Immune checkpoint inhibitor Immune-related adverse events Cytopenia Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Chinese Journal of Lung Cancer, Vol 22, Iss 10, Pp 676-680 (2019)
Druh dokumentu:	article
ISSN:	1009-3419 1999-6187
DOI:	10.3779/j.issn.1009-3419.2019.10.13
Popis:	Immune checkpoint inhibitors are able to reactivate the immune system therefore enhance the anti-tumor effects. However, over-activated T cells may induce immune related adverse events (irAEs). Hematological irAEs are rarely reported, which mainly represent as mono-lineage cytopenia or pancytopenia, including autoimmune hemolytic anemia (AIHA), immune thrombocytopenia (ITP), neutropenia and aplastic anemia, sometimes even lethal, such as hemophagocytic lymphohistiocytosis. The clinical manifestations of hematological irAEs will be summarized and recommendations of diagnosis and treatment are proposed.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/7f7c111f5fa545d6b122101eadd4c446 Zobrazit plný text záznamu View record in DOAJ