| Autor: |
Li Xue, Lu Lihong, Hou Wenting, Huang Ting, Chen Xiangyuan, Qi Jie, Zhao Yanjun, Zhu Minmin |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Acta Biochimica et Biophysica Sinica, Vol 54, Pp 163-172 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
1672-9145 |
| DOI: |
10.3724/abbs.2021016 |
| Popis: |
Diabetic nephropathy (DN), which is a common microvascular complication with a high incidence in diabetic patients, greatly increases the mortality of patients. With further study on DN, it is found that epigenetics plays a crucial role in the pathophysiological process of DN. Epigenetics has an important impact on the development of DN through a variety of mechanisms, and promotes the generation and maintenance of metabolic memory, thus ultimately leading to a poor prognosis. In this review we discuss the methylation of DNA, modification of histone, and regulation of non-coding RNA involved in the progress of cell dysfunction, inflammation and fibrosis in the kidney, which ultimately lead to the deterioration of DN. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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