A very low thymus function identifies patients with substantial increased risk for long-term mortality after kidney transplantation

Autor:	Michiel G. H. Betjes, Anton W. Langerak, Mariska Klepper, Nicolle H. R. Litjens
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Kidney transplantation Mortality Premature ageing Thymus naïve T cells recent thymic emigrants Immunologic diseases. Allergy RC581-607 Geriatrics RC952-954.6
Zdroj:	Immunity & Ageing, Vol 17, Iss 1, Pp 1-10 (2020)
Druh dokumentu:	article
ISSN:	1742-4933
DOI:	10.1186/s12979-020-00175-z
Popis:	Abstract Background End-stage renal disease is associated with premature ageing of the T cell immune system but inter-individual variation is substantial. The hypothesis was tested that advanced immunological T cell ageing assessed by peripheral T cell differentiation increases the long-term mortality risk after renal transplantation. Results Circulating T cells of 211 recipients of a kidney from a living donor were analyzed before and in the first year after transplantation. The number of CD31-positive naive T cells (as a marker for recent thymic emigrants) and the differentiation status of the memory T cells was assessed. Thirty recipients died during follow-up of at least 5 years. Absolute numbers of naive CD4+ (living:258 cells/μl vs. deceased:101 cells/μl, p
Databáze:	Directory of Open Access Journals
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