Prediction of preload dependency using phenylephrine-induced peripheral perfusion index during general anaesthesia: a prospective observational study

Autor: Yusuke Iizuka, Koichi Yoshinaga, Shizuka Amitani, Seiya Nishiyama, Kentaro Fukano, Keika Miyazawa, Asuka Kitajima, Ikumi Sawada, Yuji Otsuka, Masamitsu Sanui
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: BMC Anesthesiology, Vol 24, Iss 1, Pp 1-14 (2024)
Druh dokumentu: article
ISSN: 1471-2253
DOI: 10.1186/s12871-024-02478-w
Popis: Abstract Background Tracking preload dependency non-invasively to maintain adequate tissue perfusion in the perioperative period can be challenging.The effect of phenylephrine on stroke volume is dependent upon preload. Changes in stroke volume induced by phenylephrine administration can be used to predict preload dependency. The change in the peripheral perfusion index derived from photoplethysmography signals reportedly corresponds with changes in stroke volume in situations such as body position changes in the operating room. Thus, the peripheral perfusion index can be used as a non-invasive potential alternative to stroke volume to predict preload dependency. Herein, we aimed to determine whether changes in perfusion index induced by the administration of phenylephrine could be used to predict preload dependency. Methods We conducted a prospective single-centre observational study. The haemodynamic parameters and perfusion index were recorded before and 1 and 2 min after administering 0.1 mg of phenylephrine during post-induction hypotension in patients scheduled to undergo surgery. Preload dependency was defined as a stroke volume variation of ≥ 12% before phenylephrine administration at a mean arterial pressure of
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