Serum Level of Vitamin D in Patients with Salivary Gland Tumors
| Autor: | Sedigheh Moayedi, Bijan Khademi, Mahyar Malekzadeh, Golnoush Farzinnia, Zohreh Jaafari-Ashkavandi |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Iranian Journal of Otorhinolaryngology, Vol 35, Iss 5, Pp 273-279 (2023) |
| Druh dokumentu: | article |
| ISSN: | 2251-7251 2251-726X |
| DOI: | 10.22038/ijorl.2023.69088.3346 |
| Popis: | Introduction:The active vitamin D metabolites have anticancer effects on many human neoplasms. The vitamin D receptors have been detected in salivary glands tissue. This study aimed to evaluate the serum level of vitamin D in patients with malignant and benign salivary gland tumors.Materials and Methods:In this retrospective and cross-sectional study, 151 participants, including 42 patients with benign, 42 malignant salivary gland tumors, and 67 healthy subjects, participated. The serum level of vitamin D was measured using an enzyme-linked immunosorbent assay (ELISA).Results:The mean serum level of vitamin D was 42.7 ng/mL in patients with benign tumors, 40 ng/mL in malignant tumors, and 36.7 ng/mL in the control group. There was no significant difference between the mean vitamin D level and vitamin D status in patients with salivary gland tumors and normal controls (P=0.2). There was a significant positive correlation between vitamin D level and age in the control group (P=0.04).Conclusions:The results showed a high prevalence rate of vitamin D deficiency/insufficiency in salivary gland tumors and normal subjects, with no significant difference. Therefore, the serum level of vitamin D might not play a significant role in the pathogenesis of these tumors, similar to many human cancers. However, further prospective studies are recommended focusing on specific tumors and considering other interventional factors. |
| Databáze: | Directory of Open Access Journals |
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