Epistaxis presenting as sentinel feature of metastatic renal cell carcinoma: A case report and review of literature

Autor: Satish K Ranjan, Ankur Mittal, Sunil Kumar, Kim J Mammen, Shiv C Navariya, Deepak P Bhirud
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Journal of Family Medicine and Primary Care, Vol 9, Iss 7, Pp 3766-3769 (2020)
Druh dokumentu: article
ISSN: 2249-4863
DOI: 10.4103/jfmpc.jfmpc_497_20
Popis: About 30% of all newly diagnosed renal cell carcinoma (RCC) patients present with synchronous metastatic disease. Usual organs of involvement are lung (75%), soft tissues (36%), bone (20%), liver (18%), cutaneous sites (8%), and central nervous system (8%). Metastases to the paranasal sinuses (PNS) are relatively common and may be a part of synchronous multiorgan involvement or present in follow-up after radical nephrectomy (metachronous); but primary presentation as isolated paranasal mass before the diagnosis of RCC is extremely rare. Here, we report a case of 74-year-old female presented with epistaxis and nasal obstruction. On evaluation by magnetic resonance imaging (MRI), a heterogeneously enhancing mass was found involving left PNS. Biopsy from mass revealed clear cell RCC. Later on, contrast-enhanced computed tomography (CECT) of chest, abdomen, and pelvis showed enhancing mass from the upper pole of the left kidney with no evidence of metastasis elsewhere. The patient was started on pazopanib 800 mg once a day. At 6 months follow-up scan, there was a partial response at both primary as well as metastatic site.
Databáze: Directory of Open Access Journals
Nepřihlášeným uživatelům se plný text nezobrazuje