Hepatitis A seroprevalence in Western Cape Province South Africa: Are we in epidemiological transition
| Autor: | A Enoch, D Hardie, B Kagina, G Hussey |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | South African Medical Journal, Vol 109, Iss 5, Pp 314-318 (2019) |
| Druh dokumentu: | article |
| ISSN: | 2078-5135 0256-9574 |
| DOI: | 10.7196/SAMJ.2019.v109i5.13410 |
| Popis: | Background. Hepatitis A virus (HAV) is the most common cause of viral hepatitis worldwide. Hepatitis A vaccine is not included in the Expanded Programme on Immunisation in South Africa (EPI-SA), as the country is considered to be highly endemic for hepatitis A.Objectives. To determine the seroprevalence of hepatitis A infection in Western Cape Province (WCP), South Africa.Methods. We conducted a cross-sectional seroprevalence study in the 1 - 7-year age group in WCP. Our samples (N=482) were blood specimens left over after laboratory testing obtained from referral hospitals between August and October 2015. A Siemens enzyme immunoassay was used to test for total hepatitis A antibodies. We also analysed hepatitis A immunoglobulin G antibody results from the National Health Laboratory Service (NHLS) Disa*Lab database at Groote Schuur Hospital from 2009 to 2014, and included 2009 - 2014 acute hepatitis A (immunoglobulin M-positive) surveillance data from the National Institute for Communicable Diseases to look at trends in notified acute infections over the same period.Results. Our cross-sectional study showed 44.1% seroprevalence in the 1 - 7-year age group. Hepatitis A data from the NHLS database indicated a seroprevalence of |
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