Cardiovagal Function Measured by the Deep Breathing Test: Relationships With Coronary Atherosclerosis

Autor: Gunnar Engström, Viktor Hamrefors, Artur Fedorowski, Anders Persson, Maria E. Johansson, Ellen Ostenfeld, Isabel Goncalves, Hanna Markstad, Linda S. B. Johnson, Margaretha Persson, Jonas Carlson, Pyotr G. Platonov
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 7 (2022)
Druh dokumentu: article
ISSN: 2047-9980
DOI: 10.1161/JAHA.121.024053
Popis: Background The cardiovagal function can be assessed by quantification of respiratory sinus arrhythmia (RSA) during a deep breathing test. However, population studies of RSA and coronary atherosclerosis are lacking. This population‐based study examined the relationship between RSA during deep breathing and coronary atherosclerosis, assessed by coronary artery calcium score (CACS). Methods and Results SCAPIS (Swedish Cardiopulmonary Bioimage Study) randomly invited men and women aged 50 to 64 years from the general population. CACS was obtained from computed tomography scanning, and deep breathing tests were performed in 4654 individuals. Expiration–inspiration differences (E‐Is) of heart rates were calculated, and reduced RSA was defined as E‐I in the lowest decile of the population. The relationship between reduced RSA and CACS (CACS≥100 or CACS≥300) was calculated using multivariable‐adjusted logistic regression. The proportion of CACS≥100 was 24% in the lowest decile of E‐I and 12% in individuals with E‐I above the lowest decile (P
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