| Autor: |
Yeasir Karim, Abu Eabrahim Siddique, Faruk Hossen, Mizanur Rahman, Victor Mondal, Hasan Ul Banna, M.M. Hasibuzzaman, Zubaer Hosen, Md. Shofikul Islam, Md. Khalequzzaman Sarker, Farjana Nikkon, Zahangir Alam Saud, Lian Xin, Seiichiro Himeno, Khaled Hossain |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Environment International, Vol 131, Iss , Pp - (2019) |
| Druh dokumentu: |
article |
| ISSN: |
0160-4120 |
| DOI: |
10.1016/j.envint.2019.105029 |
| Popis: |
Background: Arsenic poisoning is a public health problem worldwide. A few studies have reported the effects of arsenic exposure on adult cognitive function, but with limitations in the subject selection and exposure markers. Moreover, information regarding the association between arsenic exposure and biomarker of cognitive impairment is scarce. Objectives: We examined the associations between arsenic exposure and adult cognitive impairment using the Mini-Mental State Examination (MMSE) and the serum levels of brain-derived neurotrophic factor (BDNF), a potential biomarker of cognitive health status. Methods: We designed a cross-sectional study that recruited 693 adult (18–60 years old) subjects from the areas of low- and high‑arsenic exposure in rural Bangladesh. The subjects' arsenic exposure levels (drinking water, hair, and nail arsenic concentrations) were measured by inductively coupled plasma-mass spectroscopy. The Bangla version of the MMSE was used as a cognitive assessment tool. Serum BDNF (sBDNF) levels were assessed by immunoassay. Results: In this study, we found that average MMSE score and sBDNF level of the subjects in arsenic-endemic areas were significantly (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full Text from ScienceDirect