Successful treatment of refractory brain metastases from ALK‐positive lung cancer with lorlatinib

Autor:	Yoshiko Nakagawa, Tetsuo Shimizu, Hisato Hiranuma, Yasuhiro Gon
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	ALK‐positive lung cancer highly sensitive PCR rebiopsy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Thoracic Cancer, Vol 13, Iss 9, Pp 1431-1435 (2022)
Druh dokumentu:	article
ISSN:	1759-7714 1759-7706
DOI:	10.1111/1759-7714.14406
Popis:	Abstract A 44‐year‐old woman with ALK‐positive advanced adenocarcinoma of the lung was treated with crizotinib, and the lung lesions disappeared. The patient was treated with alectinib and chemotherapy, but brain metastases worsened; therefore, we performed an ALK resistance gene mutation test using plasma samples. Since no ALK resistance gene mutations were detected, we speculated that ALK inhibitors failed to achieve therapeutic effects due to poor transport to the central nervous system. Therefore, we switched to lorlatinib, and found a reduction in brain metastases. In ALK‐positive advanced lung cancer, plasma‐based resistance gene testing may be useful for treatment decisions.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/7f0beffe69014a8e8526b3d5fc66ba5f Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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