Stevens–Johnson syndrome/toxic epidermal necrolysis overlap syndrome due to oral phenytoin
| Autor: | J Harikrishna, Vasili Pradeep, V Devika Reddy, M Krishna Kumar, A Surekha, Pilla S Surya Durga Devi, Alladi Mohan |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Journal of Clinical and Scientific Research, Vol 10, Iss 2, Pp 115-117 (2021) |
| Druh dokumentu: | article |
| ISSN: | 2277-5706 2277-8357 |
| DOI: | 10.4103/JCSR.JCSR_15_18 |
| Popis: | Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but lethal manifestation of hypersensitivity reaction precipitated by certain drugs and viral infections. Among the drugs, it is more common with antibiotics, antiepileptics and nonsteroidal anti-inflammatory drugs. We report the case of a 14-year-old male who presented to the medicine out-patient department with a history of fever since the previous day. Four days before this, he had developed an episode of generalised tonic–clonic seizures and was initiated on oral phenytoin since then. Following admission to the medical intensive care unit, fever persisted on the 2nd day as well. The patient developed a maculopapular rash over face and trunk, ulceration over lips and skin peeling involving >10% |
| Databáze: | Directory of Open Access Journals |
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