| Autor: |
María Reyes-Batlle, Glorian Mura-Escorche, Ines Sifaoui, Alejandro Otero-Ruiz, Rosalía Alfaro-Sifuentes, Atteneri López-Arencibia, Pedro Rocha-Cabrera, Olfa Chiboub, Aitor Rizo-Liendo, Jonadab Zamora-Herrera, Carlos J. Bethencourt-Estrella, Rubén L. Rodríguez-Expósito, Desirée San Nicolás-Hernández, José E. Piñero, Jacob Lorenzo-Morales |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Pathogens, Vol 8, Iss 3, p 109 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2076-0817 |
| DOI: |
10.3390/pathogens8030109 |
| Popis: |
Acanthamoeba is a free-living amoebae genus which is present worldwide in natural and artificial environments. These amoebae are clinically important as causative agents of diseases in humans and other animals such as a fatal encephalitis or a sight threatening Acanthamoeba keratitis (AK). Lately; studies have focused on the search of novel therapeutic options for AK but also to prevent infections. Furthermore; the evaluation of commercialized products seems to be an option for this case since not clinical assays would be required. Thus; we aimed to test the amoebicidal activity of different mixtures of two commercial ophthalmic solutions: Systane® Ultra; which has already shown anti-Acanthamoeba properties; and Naviblef® Daily Care. In addition, we tested their cytotoxic effect against murine macrophages. At the individual level; Naviblef® Daily Care showed to be the most active product against Acanthamoeba spp. Nevertheless; the combinations of Systane® Ultra and Naviblef® Daily Care; showed an improvement in the activity against trophozoites and cysts of Acanthamoeba castellanii Neff. Moreover; the concentration necessary to generate cytotoxic effect against murine macrophages (J774.1) was much higher than the required for the amoebicidal and cysticidal effect achieved in the most effective mixtures. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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