Identification of significant chromatin contacts from HiChIP data by FitHiChIP

Autor: Sourya Bhattacharyya, Vivek Chandra, Pandurangan Vijayanand, Ferhat Ay
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-019-11950-y
Popis: HiChIP/PLAC-seq assay is popular for profiling 3D genome interactions among regulatory elements at kilobase resolution. Here the authors describe FitHiChIP an empirical null-based, flexible computational method for statistical significance estimation and loop calling from HiChIP data.
Databáze: Directory of Open Access Journals