Evidence for T Cell Help in the IgG Response against Tandemly Repetitive Trypanosoma cruzi B13 Protein in Chronic Chagas Disease Patients
| Autor: | Marcia Duranti, Ludmila Camargo, Gabriel Victora, Barbara Ianni, Paula Buck, Charles Mady, Jorge Kalil, Bianca Zingales, Edecio Cunha-Neto |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Journal of Parasitology Research, Vol 2012 (2012) |
| Druh dokumentu: | article |
| ISSN: | 2090-0023 2090-0031 |
| DOI: | 10.1155/2012/635873 |
| Popis: | The tandemly repetitive Trypanosoma cruzi B13 protein is an immunodominant antigen among Chagas disease patients. Such repetitive domains may behave as T-independent antigens. However, T cells can recognize B13 epitopes in an HLA class II-restricted fashion and could potentially provide cognate T cell help and boost antibody titers. We assessed whether the presence of HLA class II molecules able to present B13 epitopes to T cells could affect anti-B13 IgG levels in a cognate fashion, in both major clinical forms of chronic Chagas disease. We found no difference between anti-B13 IgG antibody levels between patients carrying HLA class II molecules associated to T cell responses or other alleles. The predominant anti-B13 IgG subclass was IgG1, with negligible IgG2, suggesting a T-dependent, noncognate help for antibody production. In addition, the finding of increased anti-B13 IgG levels in sera from CCC patients indicates that clinical presentation is associated with increased anti-B13 antibody levels. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|