| Autor: |
Mikhail Kanarskii, Julia Nekrasova, Ekaterina Kondratieva, Ilya Borisov, Elena Simenel, Yurii Sviryaev, Pranil Pradhan, Kirill Gorshkov, Alexander Shestopalov, Marina Petrova |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Sleep Medicine: X, Vol 7, Iss , Pp 100101- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2590-1427 |
| DOI: |
10.1016/j.sleepx.2023.100101 |
| Popis: |
Annotation (Abstract): Aim: The aim of our study is to assess circadian rhythms in patients with chronic critical illness due to severe brain injury in intensive care unit by establishing the relation between melatonin and cortisol secretion, considering astronomical time and the sleep-wake cycle in chronic critical illness. Materials and methods: The study included 54 adult patients with chronic critical illness who resided in the intensive care unit for at least 30 days. The level of consciousness was determined using the CRS-R scale. We did the continuous electroencephalographic (EEG) monitoring with polygraphic leads for 24 h. Also, we determined the serum levels of cortisol and melatonin using the tandem mass spectrometry method with ultra-performance liquid chromatography. Results: 90.74 % of patients had one acrophase in melatonin secretion curve, which suggests the preservation of the rhythmic secretion of melatonin. These acrophases of the melatonin rhythm occurred during the night time in 91.8 % of patients. Most of the patients (69.3 %) slept during the period from 2:00 to 4:00 a.m. The evening levels of cortisol and melatonin had an inverse relation (rs=0.61, p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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