Anti-liver fibrosis effects of the total flavonoids of litchi semen on CCl4-induced liver fibrosis in rats associated with the upregulation of retinol metabolism

Autor:	Jiongyi Yan, Yinyi Feng, Xuewan Fang, Xiaojuan Cui, Xing Xia, Fang Li, Weisheng Luo, Jianqin Liang, Jianfang Feng, Kai Yu
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	9-Cis-retinoic acid iTRAQ liver disease RXRα traditional Chinese medicine Therapeutics. Pharmacology RM1-950
Zdroj:	Pharmaceutical Biology, Vol 60, Iss 1, Pp 1264-1277 (2022)
Druh dokumentu:	article
ISSN:	13880209 1744-5116 1388-0209 10332626
DOI:	10.1080/13880209.2022.2086584
Popis:	Context The litchi semen are traditional medications for treating liver fibrosis (LF) in China. The mechanism remains unclear.Objective This study investigates the anti-liver fibrotic mechanism of the total flavonoids of litchi semen (TFL).Materials and methods Sprague-Dawley rats with carbon tetrachloride-induced LF were treated with TFL (50 and 100 mg/kg) for 4 weeks. The anti-liver fibrotic effects of TFL were evaluated and the underlying mechanisms were investigated via histopathological analysis, proteomic analysis and molecular biology technology.Results Significant anti-LF effects were observed in the high-TFL-dose group (TFL-H, p
Databáze:	Directory of Open Access Journals
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