The association between metabolic syndrome and insulin resistance with risk of cardiovascular events in different states of cardiovascular health status

Autor: Somayeh Hosseinpour‐Niazi, Siamak Afaghi, Parto Hadaegh, Maryam Mahdavi, Hossein Farhadnejad, Maryam Tohidi, Parvin Mirmiran, Fereidoun Azizi, Farzad Hadaegh
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Journal of Diabetes Investigation, Vol 15, Iss 2, Pp 208-218 (2024)
Druh dokumentu: article
ISSN: 2040-1124
2040-1116
DOI: 10.1111/jdi.14101
Popis: ABSTRACT Aims/Introduction The aim was to examine the joint effect of metabolic syndrome (MetS) and insulin resistance (IR) with ideal cardiovascular health (iCVH) status on incident cardiovascular diseases (CVDs). Materials and Methods The study included 6,240 Iranian adults ≥30 years, free of prior cardiovascular disease. Ideal cardiovascular health was determined based on American Heart Association's Life Simple 7. Metabolic syndrome was defined according to the Joint Interim Statement Criteria, and insulin resistance was defined as HOMA‐IR ≥1.85 in women and ≥2.17 in men. Multivariable Cox proportional hazard ratios (HRs) were applied to examine the impact of metabolic syndrome, and insulin resistance at various levels of iCVH status. Results During the median follow‐up of 14.0 years, 909 cases of cardiovascular disease occurred. Metabolic syndrome and insulin resistance were significantly associated with incident cardiovascular disease events. In the poor and intermediate status, metabolic syndrome increased cardiovascular disease events with HRs of 1.83 and 1.57, respectively; the corresponding values for insulin resistance in the mentioned categories were 1.91 and 1.25, respectively (P values
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