骨关节炎与2型糖尿病的风险:一项双样本孟德尔随机化分析

Autor: Xing Xing, Yining Wang, Faming Pan, Guoqi Cai
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Journal of Diabetes, Vol 15, Iss 11, Pp 987-993 (2023)
Druh dokumentu: article
ISSN: 1753-0407
1753-0393
DOI: 10.1111/1753-0407.13451
Popis: Abstract Background Physical inactivity is an independent risk factor for type 2 diabetes (T2D). Osteoarthritis (OA) is a common joint disease that limits patients' physical activity, which may increase risk of other chronic diseases including T2D. However, studies evaluating the effect of OA on T2D are scarce. This study aimed to investigate the causal effect of knee and hip OA on risk of T2D from a genetic perspective. Methods We performed two‐sample Mendelian randomization (MR) analyses to obtain nonconfounding estimates of the effect of OA on T2D risk. Single nucleotide polymorphisms (SNPs) from genome‐wide association studies were selected as genetic instruments for radiographic knee and hip OA (ie, Kellgren–Lawrence grade ≥2). The associations of these SNPs with T2D were evaluated in participants from the UK Biobank. Sensitivity analyses were conducted to test the robustness of the MR results. Results Genetic predisposition of knee but not hip OA was significantly associated with an increased risk of T2D (knee OA: odds ratio [OR] 1.18, 95% confidence interval (CI) 1.09–1.27, p
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