Invitation to participate in a multi-center study for validation of cerebral computed tomography angiography and computed tomography perfusion in the determination of cerebral circulatory arrest during brain death/death by neurological criteria diagnosis procedure in paediatric population below 12 years of age
| Autor: | Romuald Bohatyrewicz, Joanna Sołek-Pastuszka, Wojciech Walas, Katarzyna Sznajder, Andrzej Falba, Katarzyna Chamier-Ciemińska, Wojciech Poncyljusz, Wojciech Dąbrowski, Beata Rybojad, Magdalena Woźniak, Joanna Wojczal, Piotr Luchowski, Marzena Zielińska, Maciej Guziński, Katarzyna Sierakowska, Tamara Kołakowska, Zbigniew Serafin, Alicja Bartkowska-Śniatkowska, Katarzyna Jończyk-Potoczna, Krzysztof Kobylarz, Elżbieta Byrska-Maciejasz, Łukasz Wyrobek, Andrzej Piotrowski, Elżbieta Jurkiewicz, Andrzej Kościesza, Marek Migdał, Mariola Tałałaj, Piotr Jakubów, Jacek Robert Janica, Izabela Pągowska-Klimek, Michał Brzewski, Paweł Jurszewicz, Maria Dziejowska, Elżbieta Milewicz-Podgórska, Monika Bekiesinska-Figatowska, Edyta Szurowska, Radoslaw Owczuk, Krzysztof Kusza, Marcin Sawicki |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Anaesthesiology Intensive Therapy, Vol 53, Iss 2, Pp 97-102 (2021) |
| Druh dokumentu: | article |
| ISSN: | 1642-5758 1731-2531 |
| DOI: | 10.5114/ait.2021.107189 |
| Popis: | In recent years commensal microorganisms are not just “passive occupants”, but important element of homeostasis. There are numerous reports documenting the composition and role of the gut, skin or vagina microbiome but the role of commensal organisms living in the lungs is relatively unknown. Pulmonary microbiome impact on the immune response of the host organism and may indicate new therapeutic directions. Lung microbiome, by modulating the expression of innate immunity genes, causes an increase in the concentration of IL-5, IL-10, IFNγ and CCL11, affects the TLR4 dependent response of pulmonary macrophages and modulate the production of antibacterial peptides contained in the mucus. It is documented that disorders of the lung microbiome contribute to asthma or chronic obstructive pulmonary disease. However it is known that pulmonary dysbiosis also occurs in critically ill patients. It is possible, therefore, that microbiota-targeted therapy may constitute the future therapeutic direction in ICU. |
| Databáze: | Directory of Open Access Journals |
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