Characterization of tongue coating microbiome from patients with colorectal cancer
| Autor: | Qubo Chen, Xiaoting Huang, Haiyan Zhang, Xuanting Jiang, Xuan Zeng, Wanhua Li, Hairong Su, Ying Chen, Fengye Lin, Man Li, Xiangyu Gu, Huihui Jin, Ruohan Wang, Dechang Diao, Wei Wang, Jin Li, Sufen Wei, Weizheng Zhang, Wofeng Liu, Zhiping Huang, Yusheng Deng, Wen Luo, Zuofeng Liu, Beiping Zhang |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Journal of Oral Microbiology, Vol 16, Iss 1 (2024) |
| Druh dokumentu: | article |
| ISSN: | 20002297 2000-2297 |
| DOI: | 10.1080/20002297.2024.2344278 |
| Popis: | ABSTRACTBackground Tongue coating microbiota has aroused particular interest in profiling oral and digestive system cancers. However, little is known on the relationship between tongue coating microbiome and colorectal cancer (CRC).Methods Metagenomic shotgun sequencing was performed on tongue coating samples collected from 30 patients with CRC, 30 patients with colorectal polyps (CP), and 30 healthy controls (HC). We further validated the potential of the tongue coating microbiota to predict the CRC by a random forest model.Results We found a greater species diversity in CRC samples, and the nucleoside and nucleotide biosynthesis pathway was more apparent in the CRC group. Importantly, various species across participants jointly shaped three distinguishable fur types.The tongue coating microbiome profiling data gave an area under the receiver operating characteristic curve (AUC) of 0.915 in discriminating CRC patients from control participants; species such as Atopobium rimae, Streptococcus sanguinis, and Prevotella oris aided differentiation of CRC patients from healthy participants.Conclusion These results elucidate the use of tongue coating microbiome in CRC patients firstly, and the fur-types observed contribute to a better understanding of the microbial community in human. Furthermore, the tongue coating microbiota-based biomarkers provide a valuable reference for CRC prediction and diagnosis. |
| Databáze: | Directory of Open Access Journals |
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