DRUG-INDUCED ENCEPHALOPATHY WITH IMPAIRED COGNITIVE FUNCTIONS DURING TOCILIZUMAB USE

Autor:	P. A. Shesternya, S. V. Prokopenko, E. Yu. Mozheiko, O. D. Gritsenko, T. V. Tupaeva, E. M. Kurts
Jazyk:	ruština
Rok vydání:	2019
Předmět:	tocilizumab rheumatoid arthritis interleukin-6 adverse reaction cognitive dysfunction tofacitinib Diseases of the musculoskeletal system RC925-935
Zdroj:	Научно-практическая ревматология, Vol 57, Iss 4, Pp 482-485 (2019)
Druh dokumentu:	article
ISSN:	1995-4484 1995-4492
DOI:	10.14412/1995-4484-2019-482-485
Popis:	Blockade of interleukin-6 (IL-6) is one of the most promising areas in the treatment of a number of immunoinflammatory diseases. Tocilizumab (TCZ), the first registered anti-IL-6 receptor monoclonal antibody, has been used effectively by rheumatologists since 2010. During this period, the spectrum of adverse reactions (ARs) of TCZ has been clearly defined. However, the multifaceted biological effects of IL-6 determine the probability of unexpected ARs. The article describes a clinical case of drug-induced encephalopathy with cognitive dysfunction during TCZ therapy.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/7ebdd2636886474eaf71713fdcc6ddaf Zobrazit plný text záznamu View record in DOAJ