Overcoming the thermodynamic equilibrium of an isomerization reaction through oxidoreductive reactions for biotransformation

Autor: Jing-Jing Liu, Guo-Chang Zhang, Suryang Kwak, Eun Joong Oh, Eun Ju Yun, Kulika Chomvong, Jamie H. D. Cate, Yong-Su Jin
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-019-09288-6
Popis: A desired product cannot be obtained at higher concentration than its equilibrium concentration when isomerases are used for biotransformation. Here, the authors engineer in vivo oxidoreductive reactions in yeast to overcome the equilibrium limitation of in vitro isomerases-based tagatose production.
Databáze: Directory of Open Access Journals